Ligaments2024
ACL Reconstruction: 3-Incision Technique With Allograft Quad Tendon
Stone KR
Reproducible technique avoiding autograft harvest
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Stone Research Foundation
We Unlock
Treatments
Pioneering regenerative orthopaedic techniques that accelerate healing, enabling people to stay active for life.
0+
Years of Research
Continuous investigation since 1991
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Published Studies
Peer-reviewed publications
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Patients Studied
Long-term outcomes tracked
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Year Longest Follow-up
Paste graft outcomes study
The Challenge
A Global Crisis
By 2040, one in four adults will have doctor-diagnosed arthritis—the wearing away of bone and cartilage in joints, often after sports injuries.
650M+
people worldwide suffering from arthritis
50%
of patients unable to hold a full-time job within 10 years of onset
1 in 4
people cannot perform daily tasks due to arthritis
The Solution
Repair. Regenerate.
Replace Tissues.
We develop impactful regenerative techniques and share our discoveries with medical professionals around the globe.
Accelerate healing
Treat & prevent arthritis
Avoid joint replacement
58
peer-reviewed publications
145
podium presentations
83
fellows & interns trained
$2M+
in research grants
Landmark Findings
Research that has changed how we approach biologic joint repair.
PASTE GRAFT OUTCOMES
19.1 Years
Longest follow-up study demonstrating sustained benefit of articular cartilage paste grafting for knee arthritis.
Read StudyMENISCUS SURVIVAL
89.4%
Meniscus allograft transplant survival rate at minimum 2-year follow-up, restoring knee function.
Read StudyXENOGRAFT ACL
20 Years
First proof that processed porcine tissue can successfully reconstruct human ACL ligaments.
Read Study30+ Years of Innovation
Key milestones in our journey to advance biologic joint repair.
1991cartilage
Paste Graft Technique Developed
Dr. Stone develops the articular cartilage paste grafting technique.
1997cartilage
First Surgical Technique Published
Operative Techniques in Orthopaedics publishes the paste graft method.
2003meniscus
Three-Tunnel Technique
Improved meniscus allografting technique published in Arthroscopy.
2003ligament
Xenograft ACL Trial Begins
FDA-approved pilot study of humanized porcine ACL reconstruction.
2006meniscus
Meniscus Survival Study
89.4% survival rate in arthritic knees challenges conventional contraindications.
2006cartilage
Paste Graft 2-12 Year Outcomes
85.6% success rate with 63.6% showing cartilage regeneration on biopsy.
2007meniscus
Meniscal Sizing Protocol
Height, weight, and gender established as predictors for tissue matching.
2016cartilage
Paste Graft 10-23 Year Follow-up
Median benefit time of 19.1 years—one of longest follow-ups in literature.
2020cartilage
Morselization Mechanism Discovered
Study shows impaction stimulates chondrocyte proliferation, not cell death.
2023ligament
Xenograft 20-Year Success
Proof-of-principle that humanized porcine tissue can become autologous ACL.
2024ligament
3-Incision ACL Technique
Reproducible quad tendon allograft technique published.
Our Focus
These studies provide pathways for doctors to solve sports injuries and treat osteoarthritis.
Our research answers critical questions that advance the science of regenerative medicine and improve patient outcomes worldwide.
1
Do injections of growth factors improve osteoarthritis?
2
Can healing from surgery be accelerated by growth factor injections?
3
Can meniscus regeneration be improved by a new collagen scaffold?
4
Can post-surgery muscle loss be prevented with testosterone injections?
5
Can cartilage regeneration be enhanced with paste graft additives?
6
Can biological knee reconstruction outcomes be improved?
7
Can Lab-On-A-Chip create personalized medicine for sports injuries?
Browse Research Papers
Filter and explore our peer-reviewed publications by category.
Showing 7 of 7 studies
Ligaments2023
Xenograft Bone-Patellar Tendon-Bone ACL Reconstruction: A Case Series at 20-Year Follow-up
Stone KR, Walgenbach AW, Turek TJ, Crues JV, Galili U
First proof humanized porcine tissue becomes autologous ACL
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Articular Cartilage2020
Osteochondral Autograft Plugs versus Paste Graft: Ex Vivo Morselization Increases Chondral Matrix Production
Grande D, Goldstein T, Turek TJ, et al.
Morselization increases chondrocyte proliferation 34-80%
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Articular Cartilage2016
Articular Cartilage Paste Graft for Severe Osteochondral Lesions of the Knee: A 10- to 23-Year Follow-up Study
Stone KR, Pelsis JR, Na K, Walgenbach AW, Turek TJ
19.1 year median benefit time; 90% good-excellent pain relief
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Meniscus2007
Meniscal Sizing Based on Gender, Height, and Weight
Stone KR, Freyer A, Turek T, Walgenbach AW, Wadhwa S, Crues J
Height/weight/gender correlate with meniscal dimensions
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Articular Cartilage2006
Articular Cartilage Paste Grafting to Full-Thickness Articular Cartilage Knee Joint Lesions: A 2- to 12-Year Follow-up
Stone KR, Walgenbach AW, Freyer A, Turek TJ, Speer DP
85.6% success rate; 63.6% biopsy cartilage regeneration
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Meniscus2006
Meniscus Allograft Survival in Patients with Moderate to Severe Unicompartmental Arthritis
Stone KR, Walgenbach AW, Turek TJ, Freyer A, Hill MD
89.4% survival rate in arthritic knees
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Create Exponential Impact
Why Support This Research?
1
Accelerate Healing
Reduce injury time and treat & prevent arthritis with cutting-edge biologic techniques.
2
Fund Innovation
Support research that develops regenerative techniques to repair, regenerate, and replace tissues.
3
Train Leaders
Educate students and doctors worldwide to advance treatments in orthopaedics.
Grant Funding
The California Institute of Regenerative Medicine (CIRM) and private grants awarded SRF over $2 million in 2022 to advance regenerative solutions for arthritis.
Explore the Library
Dive into three decades of peer-reviewed research and surgical education.
Join Our Mission
Help us pioneer treatments that enable people to stay active for life.